Published: Jun 22, 2021
 
 
     
 
Keywords:
Cost Effectiveness Utility Grave’s disease
 
     
 
   
 
 
 
 
 
 
 
 
 
 
 

 

 
   
 
 
 
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    Home / Archives / Vol. 17 No.1 (2564): ่January - Jane 2021 / Research Article  
 
   
 

Cost-utility and cost-effectiveness analysis of anti-thyroid drug and radioactive iodine in Graves' disease patient: A prospective study

   
 
   
   
     
 
พิศาล ชุ่มชื่น
โรงพยาบาลดำเนินสะดวก
วลีรัตน์ วงษ์เกษม
ฉัตราภรณ์ ชุ่มจิต

Abstract

Objective: To study the therapeutic effect between the anti-thyroid hormone drugs compared (ATD) with the radioactive iodine (RAI) in the aspect of quality of life, cost, and effectiveness in Graves’ disease (GD).


Materials and Methods: The study was established in Damnoensaduak Hospital, Thailand, between July 2014 to July 2020. A total of 182 patients with GD were enrolled in the study (151 and 31 patients treated with ATD and RAI, respectively). The health utility (quality of life data) were collected before and after participating in the program measured by the EuroQol (EQ-5D) (Thai version). Cost-effectiveness evaluation from the costs invested in increasing one level of quality of life in each person was estimated. The health utility and cost were measured by using the comparison of the treatment outcomes between each treatment modality was made by an independent t-test.


Results: After two years of the following periods, the RAI treatment group show a higher significant cost than the ATD group (p< 0.01). The patients in the RAI treatment group also show a significant improvement in the quality of life than the ATD group; in terms of the utility score (p=0. 034) and remission rate (p<0.01). Cost-utility in the RAI treatment group and the ATD group provider views were 20,186.76 baht and 12,305.83 baht, respectively, and Cost-effectiveness in the RAI treatment group and the ATD group provider view were 578.93 baht and 120.07 baht, respectively.


Conclusions:  RAI demonstrated a better improvement of cure rate and the health utility than the ATD, but the RAI is a higher cost for treatment strategy for GD.

 
     
     
 
    How to Cite  
     
  ชุ่มชื่น พ., วงษ์เกษม ว., & ชุ่มจิต ฉ. (2021). Cost-utility and cost-effectiveness analysis of anti-thyroid drug and radioactive iodine in Graves’ disease patient: A prospective study. Journal of Charoenkrung Pracharak Hospital17(1), 30–46. Retrieved from https://he02.tci-thaijo.org/index.php/JCP/article/view/246877  
     

 
 
     
     
 
    Issue  
     
  Vol. 17 No. 1 (2564): ่January - Jane 2021  

 
 
     
     
 
    Section  
     
  Research  article  

 
 
     
     
     
 

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